| Classes usually taught:
Awards and Funding: |
Awards: Summer 2006: Turner
Biosystems - Grant for Modulus Fluorometer
http://www.multimode-reader.org
Summer 2005: NSF
Summer Research Fellow at the University of Tennessee,
under the Research Site for Educators in Chemistry (RSEC)
Summer 2004: NSF Summer Research
Fellow at the University of Tennessee, under the
Research Site for Educators in Chemistry (RSEC)
Funding:
http://www.multimode-reader.org
Ciba Specialty Chemicals
Anne McDonald Family Foundation
Englehard Specialty Chemicals |
| Academic or Research
Interests: |
Separation
science, especially chromatography, is a discipline of
analytical chemistry that is rigorous.
It is used to separate, isolate, and quantify
compounds from a complex mixture.
For example, pharmaceutical companies use
chromatography to isolate a product from a reaction
mixture, to isolate active components from natural
products, and to identify possible breakdown products of
medicines. Environmental
chemists use chromatography to quantify the amount of a
solute present in a sample and to assess the fate and
transport of a compound in the environment.
My goals are to develop novel stationary phases
and to investigate partitioning mechanisms.
Development
of Stationary and Pseudo Stationary Phases for Capillary
Electrophoresis Techniques
Capillary
Electrophoresis techniques have been the cutting edge of
research for the past several years.
It is known for its efficiency; however, use in
many areas is limited due to shortcomings in
reproducibility, cost effectiveness, and general
understanding of separation mechanisms.
Although a lot of research has focused on
adjusting the mobile phases to enhance separation, my
research interests involve the development of stationary
phases to enhance or improve separation in improve the
separation of chiral and hydrophobic molecules.
To measure the effectiveness of these stationary
phases I will utilize the following Electro-separation
techniques using aqueous and non-aqueous mobile phases:
micellar electrokinetic chromatography (MEKC) and
capillary electrochromatography (CEC).
The
stationary phases will also be different.
To take advantage of ease of synthesis,
dendrimers will be used to manufacture stationary and
pseudo-stationary phases. Dendrimers are an example of an ideal polymer whose size,
functionality, and other physical properties can be
controlled. If
I can control these variables, I can increase the
selectivity and efficiency of the separation of a
mixture. My
research in this area will shed some light to the
general understanding of these techniques and the
development innovative separation techniques, if
successful.
Partitioning
Mechanisms of Chiral/Achiral Stationary Phases
Separating
chiral compounds are very important to the
pharmaceutical industry.
It is well known that many diastereomers of a
chiral compound may have adverse effects on the human
body. In
many cases, the separation of these compounds is by
trial and error. My research projects will focus on the prediction of chiral
separations. Many
research groups use Linear Solvation Energy
Relationships (LSER) as a predictor for partitioning
processes. However,
the use of LSER as a predictor of chiral separations is
limited. LSER
is a multivariable relationship that describes
partitioning mechanisms as a function of various
solute/solvent interactions. These interactions may explain chiral separations; and
if not, I plan to determine which solute/solvent
interactions are prevalent in chiral separations.
I plan to develop chiral dendrimeric stationary
phases. Investigation
of different chiral stationary phases may indicate which
molecular interactions can affect the partitioning of
chiral and achiral compounds.
|
| Recent Publications: |
- D. J. Bailey and J. G.
Dorsey, “Linear Solvation Energy Relationships of
Mixed Micelles Containing Sodium Dodecyl Sulfate and
Decanol: Towards a Better Model of Octanol-Water
Partitioning”, Journal of Chromatography A, 919
(2001) 181-194.
- D. J. Bailey and J. G.
Dorsey, "pH effects on micelle-water
partitioning determined by micellar electrokinetic
chromatography", Journal of Chromatography A,
852, (1999), 559-571.
|
